職位描述
?Participate in the purification method development of antibodies and protein drugs, including buffer screening, resin screening, method optimization of different chromatography techniques (affinity, ion exchange, hydrophobic interaction and Gel Filtration) and ultrafiltration.
?參與抗體和蛋白藥物的純化方法開發(fā),包括緩沖液篩選、填料篩選、不同層析技術(shù)方法優(yōu)化(親和、離子交換、疏水相互作用和凝膠過濾)和超濾。
?Perform simple characterization of purified products, such as SDS-PAGE, protein concentration, SEC-HPLC, endotoxin test etc.
?對純化產(chǎn)物進(jìn)行簡單分析,例如蛋白濃度測定、 SDS-PAGE、SEC-HPLC 、內(nèi)毒素檢測等。
?Good communication and close cooperation with upstream, analysis and formulation colleagues to ensure the smooth development of team work.
?與上游,分析和制劑同事良好溝通緊密配合,保證團(tuán)隊(duì)工作開展。
?Ensures the integrity and authenticity of experiment records and the reliability of data.
?確保試驗(yàn)記錄真實(shí)完整,實(shí)驗(yàn)數(shù)據(jù)科學(xué)可靠。
?Independently operates, troubleshoots, and maintains purification equipment.
?獨(dú)立操作和維護(hù)相關(guān)的純化儀器設(shè)備,并解決常見問題。
?Ensures that experimental operations and related activities comply with SOP and EHS requirements.
?確保與試驗(yàn)有關(guān)的活動(dòng)符合相關(guān)SOP和EHS要求。
Requirements:
?Familiarity with various chromatography principles, the properties of resins, and the operation of AKTA purification equipment.
?熟悉各種層析原理、介質(zhì)填料的性質(zhì)以及AKTA純化設(shè)備的具體操作。
?Able to independently complete the design and implementation of protein purification process development, process optimization, and process scale-up.
?能獨(dú)立完成蛋白純化工藝開發(fā)、工藝優(yōu)化、工藝放大的方案設(shè)計(jì)并實(shí)施。
?Strong organization and coordination skills, good team spirit, strong analytical and problem-solving skills.
?有較強(qiáng)的組織協(xié)調(diào)能力、良好的團(tuán)隊(duì)精神、較強(qiáng)的分析和解決問題的能力
?Strong learning ability, willing to explore new technology, proactive to search solutions or look for support when facing challenges at daily work.
?有較強(qiáng)的學(xué)習(xí)能力、積極主動(dòng)地學(xué)習(xí)新技術(shù),工作中遇到挑戰(zhàn)時(shí)能主動(dòng)尋找方案或?qū)で髱椭??Fluent in English.
?英語熟練。
Education Required:
?Master’s degree in engineering, Chemistry, Biology, Biotechnology or related field;
?工程、化學(xué)、生物、生物技術(shù)等相關(guān)專業(yè)碩士學(xué)位;
?with 3 years of work experience in purification.
?有3年的純化工作經(jīng)驗(yàn)。